Development of a physiological microsystem, from a blood-brain barrier-on-chip to a vascularized glioblastoma-on-chip
Résumé
The blood-brain barrier (BBB) limits the transport of drugs and nanocarriers, and hampers the development of innovative therapeutic solutions against neurological disorders. The fight against most common and aggressive brain tumor, the glioblastoma multiforme (GBM), faces too many therapeutic failures, with a survival after diagnosis of 12 to 18 months only. The preclinical screening of innovative drug candidates relies on conventional 2D in vitro models which may be too simplistic, and animal experimentation with ethical issues and interspecies differences. Poor translational results in clinical assays are unfortunately the norm. Tissue engineering and physiological microsystems, as organ-on-chips, promise alternative models that mimic a complex microenvironment in healthy or pathological contexts: the 3D organization of different human cell types, the extracellular matrix, and the chemical gradients and mechanical constraints of the blood flow.
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Soumis le : mercredi 28 août 2024-15:47:27
Dernière modification le : samedi 31 août 2024-03:05:49
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- HAL Id : hal-04680288 , version 1
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Agathe Figarol, Roumaïssa Mosbah, Michiya Matsusaki, Asuka Yamada, Tomomi Furihata, et al.. Development of a physiological microsystem, from a blood-brain barrier-on-chip to a vascularized glioblastoma-on-chip. Cancéropole Grand Sud-Ouest, Nov 2023, ARCACHON, France. ⟨hal-04680288⟩
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